Protein Biophysics at DTU Bioengineering

• H. Mohammad-Beigi, T. O. Mason, T. A. M. Rovers, T. C. Jæger, M. S. Møller, R. Ipsen, A. B. Hougaard, B. Svensson & A. K. Buell.
  Taylor Dispersion Analysis of Micellization (TDAM) Reveals Distinct Assembly and Dissociation Pathways of α-, β-, and κ-Casein Micelles.
  Food Hydrocolloids, 2025. 112301. ISSN 0268-005X.
  DOI: 10.1016/j.foodhyd.2025.112301
• S. Wang, L. Boyens-Thiele, M. Bićanin, B. Svensson, A. K. Buell & M. S. Møller.
  Heterologous Production and Characterization of Rapeseed Procruciferin Isoforms for Sustainable Food Protein Development.
  Sustainable Food Proteins, 2025. 3(4): e70040.
  DOI: 10.1002/sfp2.70040
• C. Fricke, A. Kunka, R. K. Norrild, S. Wang, T. L. Dang, J. Folke, M. Shahnawaz, C. Soto, S. Aznar, A. S. Wentink, B. Bukau & A. K. Buell.
  Thermodynamic stability modulates chaperone-mediated disaggregation of α-synuclein fibrils.
  Chemical Science, 2025, (Accepted/In press), Article d5sc04927j.
  DOI: 10.1039/d5sc04927j
• F. T. Tucholski, R. Sternke-Hoffmann, T. Pauly, R. K. Norrild, A. Boquoi, R. Fenk, L. Nagel, A. K. Buell, R. Haas & D. Willbold.
  Tracking reduction-induced molecular changes in pathological free light chains by SV-AUC.
  European Biophysics Journal, 2025. 54, p. 365–383.
• J. A. Larsen, A. Barclay, N. Vettore, L. K. Klausen, L. N. Mangels, A. Coden, J. D. Schmit, K. Lindorff-Larsen & A. K. Buell.
  The mechanism of amyloid fibril growth from Φ-value analysis.
  Nature Chemistry, 2025. 17, p. 403–411.
• A. Farzadfard, T. O. Mason, A. Kunka, H. Mohammad-Beigi, K. Bjerregaard-Andersen, J. Folke, S. Aznar, P. Kallunki & A. K. Buell.
  The amplification of alpha-synuclein amyloid fibrils is suppressed under fully quiescent conditions.
  Angewandte Chemie – International Edition, 2025. 64, 7, 10 p., e202419173.
• S. Jäger, J. Tittelmeier, T. L. Dang, T. Bellande, V. Redeker, A. K. Buell, J. Hennig, R. Melki, C. Nussbaum-Krammer, B. Bukau & A. S. Wentink.
  Structural polymorphism of α-synuclein fibrils alters the pathway of Hsc70-mediated disaggregation.
  EMBO Journal, 2025. 44, p. 6499–6526.
• L. Zhai, Z. Wang, F. Liu, C. Xu, J. Wang, H. Han, Q. Xie, W. Zhang, Y. Zheng, A. K. Buell & Y. Dong.
  Semi-rational evolution of a recombinant DNA polymerase for modified nucleotide incorporation efficiency.
  PLOS ONE, 2025. 20, 2, 28 p., e0316531.
• J. Aunstrup Larsen, J. H. M. van Gils, S. Ray, M. Dickmanns, S. Wang, A. Sadek, H. Mohammad-Beigi, M. Zanganeh, S. Abeln & A. K. Buell.
  Probing the effect of the disordered flank regions on amyloid fibril growth and proliferation.
  RSC Advances, 2025. 15, 26, p. 20668–20681.
• C. Fricke, J. Milošević, A. Carlsson, L. Boyens-Thiele, M. Dubackic, U. Olsson, A. K. Buell & S. Linse.
  On the thermal and chemical stability of DNAJB6b and its globular domains.
  Biophysical Chemistry, 2025. 320, 9 p., 107401.
• A. K. Buell.
  Induction and manipulation of biomolecular condensates through spatially heterogeneous solution conditions.
  ChemBioChem, 2025. 26, 10, 7 p., e202500044.
• A. Stevenson, R. Staats, A. J. Dear, D. Voderholzer, J. E. Dreier, G. Meisl, R. Guido, T. P. J. Knowles, C. Galvagnion, A. K. Buell, M. Vendruscolo & T. C. T. Michaels.
  Global kinetic model of lipid-induced α-synuclein aggregation and its inhibition by small molecules.
  Proceedings of the National Academy of Sciences of the United States of America, 2025. 122, 26, 9 p., e2422427122.
• N. Cannac, S. Fjermedal, J. A. Larsen, A. K. Buell & A. S. Meyer.
  A QCM-D-based continuous assay for the study of the enzymatic degradation of insoluble calcium-polygalacturonate.
  Carbohydrate Polymers, 2025. 364, 8 p., 123759.

• T Tulika, F Ruso-Julve, S Ahmadi, A Ljungars, E Rivera-de-Torre, J Wade, ML Fernández-Quintero, TP Jenkins, SB Belfakir, GMS Ross, L Boyens-Thiele, AK Buell, SA Sakya, CV Sørensen, M Bohn, L Ledsgaard, BG Voldborg, C Francavilla, T Schlothauer, B Lomonte, JT Andersen, AH Laustsen
  Engineering of pH-dependent antigen binding properties for toxin-targeting IgG1 antibodies using light-chain shuffling.
  STRUCTURE, 2024.
  DOI: 10.1016/j.str.2024.07.014
• SG Heath, SG Gray, EM Hamzah, KM O’Connor, SM Bozonet, AD Botha, P de Cordovez, NJ Magon, JD Naughton, DLW Goldsmith, AJ Schwartfeger, M Sunde, AK Buell, VK Morris, C Göbl
  Amyloid formation and depolymerization of tumor suppressor p16INK4a are regulated by a thiol-dependent redox mechanism.
  NATURE COMMUNICATIONS, 2024.
  DOI: 10.1038/s41467-024-49581-7
• A Farzadfard, TO Mason, A Kunka, K Bjerregaard-Andersen, P Kallunki, AK Buell
  The secondary nucleation of alpha-synuclein amyloid fibrils is suppressed under fully quiescent conditions.
  CHEMRXIV, 2024.
  DOI: 10.26434/chemrxiv-2024-npb8z
• KL Bøgh, DM Nielsen, H Mohammad-Beigi, HF Christoffersen, LN Jacobsen, RK Norrild, B Svensson, K Schmidthaler, Z Szépfalusi, J Upton, T Eiwegger, H Bertelsen, AL Buell, LV Sørensen, JM Larsen
  Degree of hydrolysis is a poor predictor of the sensitizing capacity of whey-and casein-based hydrolysates in a Brown Norway rat model of cow’s milk allergy.
  FOOD RESEARCH INTERNATIONAL, 2024.
  DOI: 10.1016/j.foodres.2024.114063
• S RAY, AK BUELL
  Emerging experimental methods to study the thermodynamics of biomolecular condensate formation.
  JOURNAL OF CHEMICAL PHYSICS, 2024.
  DOI: 10.1063/5.0190160
• JA Larsen, A Barclay, N Vettore, LK Klausen, L Mangels, A Coden, J Schmit, K Lindorff-Larsen, AK Buell
  The mechanism of amyloid fibril growth from Φ-value analysis.
  CHEMRXIV, 2024.
  DOI: 10.26434/chemrxiv-2024-fxvmk
• L Boyens-Thiele, AK Buell, C Schmitt, JPD Wanasundara
  Probing the structure–function relationship of proteins with molecular modeling.
  2024.
  DOI: 10.1016/B978-0-323-91721-6.00002-5
• C Galvagnion, A Barclay, K Makasewicz, FR Marlet, M Moulin, JM Devos, S Linse, A Martel, L Porcar, E Sparr, MC Pedersen, F Roosen-Runge, L Arleth, AK Buell
  Structural characterisation of α-synuclein–membrane interactions and the resulting aggregation using small angle scattering.
  PHYS. CHEM. CHEM. PHYS., 2024.
  DOI: 10.1039/D3CP05928F
• A Farzadfard, A Kunka, TO Mason, JA Larsen, RK Norrild, ET Dominguez, S Ray, AK Buell
  Thermodynamic characterization of amyloid polymorphism by microfluidic transient incomplete separation.
  CHEMICAL SCIENCE, 2024.
  DOI: 10.1039/D3SC05371G

• RK Norrild, TO Mason, L Boyens-Thiele, S Ray, JB Mortensen, AW Fritsch, JM Iglesias-Artola, LK Klausen, EGP Stender, H Jensen, AK Buell
  Taylor-dispersion induced phase separation for the efficient characterisation of protein condensate formation.
  CHEMRXIV, 2023.
  DOI: 10.26434/chemrxiv-2023-1ztrt
• S Ray, TO Mason, L Boyens-Thiele, A Farzadfard, JA Larsen, RK Norrild, N Jahnke, AK Buell
  Mass photometric detection and quantification of nanoscale α-synuclein phase separation.
  NATURE CHEMISTRY, 2023.
  DOI: 10.1038/s41557-023-01244-8
• S Nath, AK Buell, B Barz
  Pyroglutamate-modified Amyloid β (3-42) Monomer has more β-sheet content than the Amyloid β (1-42) Monomer.
  PHYS. CHEM. CHEM. PHYS., 2023.
  DOI: 10.1039/D2CP05961D
• L Zhai, Z Wang, F Liu, C Xu, J Wang, H Han, Q Xie, W Zhang, Y Zheng, AK Buell, Y Dong
  Semi-rational evolution of a recombinant DNA polymerase for modified nucleotide incorporation efficiency.
  BIORXIV, 2023.
  DOI: 10.1101/2023.03.20.533374
• C Galvagnion, A Barclay, K Makasewicz, FR Marlet, M Moulin, J Devos, S Linse, A Martel, L Porcar, E Sparr, M Cramer Pedersen, F Roosen-Runge, L Arleth, AK Büll
  Structural characterisation of α-synuclein-membrane interactions and the resulting aggregation using small angle scattering.
  CHEMRXIV, 2023.
  DOI: 10.26434/chemrxiv-2023-6hsh2
• J Shenoy, A Lends, M Berbon, M Bilal, N El Mammeri, M Bertoni, A Saad, E Morvan, A Grélard, S Lecomte, F Theillet, AK Buell, B Kauffmann, B Habenstein, A Loquet
  Structural polymorphism of the low-complexity C-terminal domain of TDP-43 amyloid aggregates revealed by solid-state NMR.
  FRONT. MOL. BIOSCI., 2023.
  DOI: 10.3389/fmolb.2023.1148302
• H Mohammad-Beigi, W Wijaya, M Madsen, Y Hayashi, R Li, TAM Rovers, TC Jæger, AK Buell, AB Hougaard, JJK Kirkensgaard, P Westh, R Ipsen, B Svensson
  Association of caseins with β-lactoglobulin influenced by temperature and calcium ions: A multi-parameter analysis.
  FOOD HYDROCOLLOIDS, 2023.
  DOI: 10.1016/j.foodhyd.2022.108373
• AV Madsen, P Kristensen, AK Buell, S Goletz
  Generation of robust bispecific antibodies through fusion of single-domain antibodies on IgG scaffolds: a comprehensive comparison of formats.
  MABS, 2023.
  DOI: 10.1080/19420862.2023.2189432
• R Sternke-Hoffmann, T Pauly, RK Norrild, J Hansen, F Tucholski, M Haraldson Høie, P Marcatili, M Dupré, M Duchateau, M Rey, C Malosse, S Metzger, A Boquoi, F Platten, SU Egelhaaf, J Chamot-Rooke, R Fenk, L Nagel-Steger, R Haas, AK Buell
  Widespread amyloidogenicity potential of multiple myeloma patient-derived immunoglobulin light chains.
  BMC BIOLOGY, 2023.
  DOI: 10.1186/s12915-022-01506-w

• H Mohammad-Beigi, W Wijaya, M Madsen, Y Hayashi, R Li, TAM Rovers, TC Jæger, AK Buell, AB Hougaard, JJK Kirkensgaard, P Westh, R Ipsen, B Svensson.
  Association of caseins with β-lactoglobulin influenced by temperature and calcium ions: A multi-parameter analysis.
  BIORXIV, 2022.
  DOI: 10.1016/j.foodhyd.2022.108373
• J Bartl, M Zanini, F Bernardi, A Forget, L Blumel, J Talbot, D Picard, N Qin, G Cancila, QS Gao, S Nath, IM Koumba, M Wolter, F Kuonen, M Langini, T Beez, C Munoz, D Pauck, V Marquardt, H Yu, J Souphron, M Korsch, C Molders, D Berger, S Gobbels, FD Meyer, B Scheffler, B Rotblat, S Diederichs, V Ramaswamy, H Suzuki, A Oro, K Stuhler, A Stefanski, U Fischer, G Leprivier, D Willbold, G Steger, A Buell, M Kool, P Lichter, SM Pfister, PA Northcott, MD Taylor, A Borkhardt, G Reifenberger, O Ayrault, M Remke.
  The HHIP-AS1 lncRNA promotes tumorigenicity through stabilization of dynein complex 1 in human SHH-driven tumors.
  NATURE COMMUNICATIONS, 2022.
  DOI: 10.1038/s41467-022-31574-z
• S Ray, TO Mason, L Boyens-Thiele, N Jahnke, AK Buell.
  Mass photometric detection and quantification of nanoscale α-synuclein phase separation.
  BIORXIV, 2022.
  DOI: 10.1101/2022.05.03.490467
• A Farzadfard, A König, SV Petersen, J Nielsen, E Vasili, A Dominguez-Meijide, AK Buell, TF Outeiro, DE Otzen.
  Glycation modulates alpha-synuclein fibrillization kinetics: A sweet spot for inhibition.
  JBC, 2022.
  DOI: 10.1016/j.jbc.2022.101848
• VL Leguizamon Herrera, AK Buell, D Willbold, B Barz.
  Interaction of Therapeutic d-Peptides with Aβ42 Monomers, Thermodynamics, and Binding Analysis.
  ACS CHEMICAL NEUROSCIENCE, 2022.
  DOI: 10.1021/acschemneuro.2c00102
• D Zhang, YQ Sheng, N Piano, T Jakuszeit, EJ Cozens, LQ Dong, AK Buell, A Pollet, IM Lei, WY Wang, E Terentjev, YYS Huang.
  Cancer cell migration on straight, wavy, loop and grid microfibre patterns.
  BIOFABRICATION, 2022.
  DOI: 10.1088/1758-5090/ac48e6
• AK Buell.
  Stability matters, too – The thermodynamics of amyloid fibril formation.
  Chem. Sci., 2022.
  DOI: 10.1039/D1SC06782F
• H Mohammad-Beigi, M Zanganeh, C Scavenius, H Eskandari, A Farzadfard, SA Shojaosadati, JJ Enghild, DE Otzen, AK Buell, DS Sutherland.
  A Protein Corona Modulates Interactions of α-Synuclein with Nanoparticles and Alters the Rates of the Microscopic Steps of Amyloid Formation.
  ACS NANO, 2022.
  DOI: 10.1021/acsnano.1c08825

• EGP Stender, S Ray, RK Norrild, JA Larsen, D Petersen, A Farzadfard, C Galvagnion, H Jensen, AK Buell.
  Capillary flow experiments for thermodynamic and kinetic characterization of protein liquid-liquid phase separation.
  NATURE COMMUNICATIONS, 2021.
  DOI: 10.1038/s41467-021-27433-y
• S Nath, P Roy, R Mandal, R Roy, AK Buell, N Sengupta, PK Tarafdar.
  Hydroxy-Porphyrin as an Effective, Endogenous Molecular Clamp during Early Stages of Amyloid Fibrillization.
  CHEMISTRY-AN ASIAN JOURNAL, 2021.
  DOI: 10.1002/asia.202100965
• DE Otzen, AK Buell, H Jensen.
  Microfluidics and the quantification of biomolecular interactions.
  CURRENT OPINION IN STRUCTURAL BIOLOGY, 2021.
  DOI: 10.1016/j.sbi.2021.02.006
• M Dupre, M Duchateau, R Sternke-Hoffmann, A Boquoi, C Malosse, R Fenk, R Haas, AK Buell, M Rey, J Chamot-Rooke.
  De Novo Sequencing of Antibody Light Chain Proteoforms from Patients with Multiple Myeloma.
  ANALYTICAL CHEMISTRY, 2021.
  DOI: 10.1021/acs.analchem.1c01955
• S Nath, AK Buell, B Barz, L Gremer, SS Linse, D Willbold.
  Pyroglumate-modified A beta(3-42) monomers bind with higher affinity than A beta 42 monomers to A beta 42 fibrils.
  EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2021.
• AK Buell.
  Editorial for the special issue “Protein misfolding and amyloid aggregation” of Biophysical Chemistry.
  BIOPHYSICAL CHEMISTRY, 2021.
  DOI: 10.1016/j.bpc.2021.106566
• B Lopez-Mendez, B Baron, CA Brautigam, TA Jowitt, SH Knauer, S Uebel, MA Williams, A Sedivy, O Abian, C Abreu, M Adamczyk, W Bal, S Berger, AK Buell, C Carolis, T Daviter, A Fish, M Garcia-Alai, C Guenther, J Hamacek, J Holkova, J Houser, C Johnson, S Kelly, A Leech, C Mas, D Matulis, SH McLaughlin, R Montserret, R Nasreddine, R Nehme, Q Nguyen, D Ortega-Alarcon, K Perez, K Pirc, G Piszczek, M Podobnik, N Rodrigo, J Rokov-Plavec, S Schaefer, T Sharpe, J Southall, D Staunton, P Tavares, O Vanek, M Weyand, D Wu.
  Reproducibility and accuracy of microscale thermophoresis in the NanoTemper Monolith: a multi laboratory benchmark study.
  EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2021.
  DOI: 10.1007/s00249-021-01532-6
• SH Alijanvand, A Peduzzo, AK Buell.
  Secondary Nucleation and the Conservation of Structural Characteristics of Amyloid Fibril Strains.
  FRONTIERS IN MOLECULAR BIOSCIENCES, 2021.
  DOI: 10.3389/fmolb.2021.669994
• RK Norrild, N Vettore, A Coden, WF Xue, AK Buell.
  Thermodynamics of amyloid fibril formation from non-equilibrium experiments of growth and dissociation.
  BIOPHYSICAL CHEMISTRY, 2021.
  DOI: 10.1016/j.bpc.2021.106549
• ED Agerschou, MP Schutzmann, N Reppert, MM Wordehoff, H Shaykhalishahi, AK Buell, W Hoyer.
  beta-Turn exchanges in the alpha-synuclein segment 44-TKEG-47 reveal high sequence fidelity requirements of amyloid fibril elongation.
  BIOPHYSICAL CHEMISTRY, 2021.
  DOI: 10.1016/j.bpc.2020.106519
• B Barz, AK Buell, S Nath.
  Compact fibril-like structure of amyloid beta-peptide (1-42) monomers.
  CHEMICAL COMMUNICATIONS, 2021.
  DOI: 10.1039/d0cc06607a

• JHM vanGils, E vanDijk, A Peduzzo, A Hofmann, N Vettore, MP Schutzmann, G Groth, H Mouhib, DE Otzen, AK Buell, S Abeln.
  The hydrophobic effect characterises the thermodynamic signature of amyloid fibril growth.
  PLOS COMPUTATIONAL BIOLOGY, 2020.
  DOI: 10.1371/journal.pcbi.1007767
• A Peduzzo, S Linse, AK Buell.
  The Properties of alpha-Synuclein Secondary Nuclei Are Dominated by the Solution Conditions Rather than the Seed Fibril Strain.
  ACS CHEMICAL NEUROSCIENCE, 2020.
  DOI: 10.1021/acschemneuro.9b00594
• R Sternke-Hoffmann, A Boquoi, DLY Niedenhoff, F Platten, R Fenk, R Haas, AK Buell.
  Biochemical and biophysical characterisation of immunoglobulin free light chains derived from an initially unbiased population of patients with light chain disease.
  PEERJ, 2020.
  DOI: 10.7717/peerj.8771
• R Sternke-Hoffmann, A Peduzzo, N Bolakhrif, R Haas, AK Buell.
  The Aggregation Conditions Define Whether EGCG is an Inhibitor or Enhancer of alpha-Synuclein Amyloid Fibril Formation.
  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020.
  DOI: 10.3390/ijms21061995

• N Vettore, AK Buell.
  Thermodynamics of amyloid fibril formation from chemical depolymerization.
  PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2019.
  DOI: 10.1039/c9cp04524d
• C Galvagnion, D Topgaard, K Makasewicz, AK Buell, S Linse, E Sparr, CM Dobson.
  Lipid Dynamics and Phase Transition within alpha-Synuclein Amyloid Fibrils.
  JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 2019.
  DOI: 10.1021/acs.jpclett.9b03005
• T Sneideris, A Sakalauskas, R Sternke-Hoffmann, A Peduzzo, M Ziaunys, AK Buell, V Smirnovas.
  The Environment Is a Key Factor in Determining the Anti-Amyloid Efficacy of EGCG.
  BIOMOLECULES, 2019.
  DOI: 10.3390/biom9120855
• AK Buell.
  The growth of amyloid fibrils: rates and mechanisms.
  BIOCHEMICAL JOURNAL, 2019.
  DOI: 10.1042/BCJ20160868
• ED Agerschou, P Flagmeier, T Saridaki, C Galvagnion, D Komnig, L Heid, V Prasad, H Shaykhalishahi, D Willbold, CM Dobson, A Voigt, B Falkenburger, W Hoyer, AK Buell.
  An engineered monomer binding-protein for alpha-synuclein efficiently inhibits the proliferation of amyloid fibrils.
  ELIFE, 2019.
  DOI: 10.7554/eLife.46112
• C Roder, N Vettore, LN Mangels, L Gremer, RB Rayelli, D Willbold, W Hoyer, AK Buell, GF Schroder.
  Atomic structure of PI3-kinase Sh5 amyloid fibrils by cryo-electron microscopy.
  NATURE COMMUNICATIONS, 2019.
  DOI: 10.1038/s41467-019-11320-8
• M Falke, J Victor, MM Wordehoff, A Peduzzo, T Zhang, GF Schroder, AK Buell, W Hoyer, M Etzkorn.
  alpha-Synuclein-derived lipoparticles in the study of alpha-Synuclein amyloid fibril formation.
  CHEMISTRY AND PHYSICS OF LIPIDS, 2019.
  DOI: 10.1016/j.chemphyslip.2019.02.009
• TO Mason, AK Buell.
  The Kinetics, Thermodynamics and Mechanisms of Short Aromatic Peptide Self-Assembly.
  BIOLOGICAL AND BIO-INSPIRED NANOMATERIALS: PROPERTIES AND ASSEMBLY MECHANISMS, 2019.
  DOI: 10.1007/978-981-13-9791-2_3

• T Ziehm, AK Buell, D Willbold.
  Role of Hydrophobicity and Charge of Amyloid-Beta Oligomer Eliminating D-Peptides in the Interaction with Amyloid-Beta Monomers.
  ACS CHEMICAL NEUROSCIENCE, 2018.
  DOI: 10.1021/acschemneuro.8b00132
• JWP Brown, G Meisl, TPJ Knowles, AK Buell, CM Dobson, C Galvagnion.
  Kinetic barriers to alpha-synuclein protofilament formation and conversion into mature fibrils.
  CHEMICAL COMMUNICATIONS, 2018.
  DOI: 10.1039/c8cc03002b
• IM vanderWateren, TPJ Knowles, AK Buell, CM Dobson, C Galvagnion.
  C-terminal truncation of alpha-synuclein promotes amyloid fibril amplification at physiological pH.
  CHEMICAL SCIENCE, 2018.
  DOI: 10.1039/c8sc01109e
• SIA Cohen, R Cukalevski, TCT Michaels, A Saric, M Tornquist, M Vendruscolo, CM Dobson, AK Buell, TPJ Knowles, S Linse.
  Distinct thermodynamic signatures of oligomer generation in the aggregation of the amyloid-beta peptide.
  NATURE CHEMISTRY, 2018.
  DOI: 10.1038/s41557-018-0023-x
• HZ Gang, C Galvagnion, G Meisl, T Muller, M Pfammatter, AK Buell, A Levin, CM Dobson, BZ Mu, TPJ Knowles.
  Microfluidic Diffusion Platform for Characterizing the Sizes of Lipid Vesicles and the Thermodynamics of Protein-Lipid Interactions.
  ANALYTICAL CHEMISTRY, 2018.
  DOI: 10.1021/acs.analchem.7b04820
• T Viennet, MM Wordehoff, B Uluca, C Poojari, H Shaykhalishahi, D Willbold, B Strodel, H Heise, AK Buell, W Hoyer, M Etzkorn.
  Structural insights from lipid-bilayer nanodiscs link alpha-Synuclein membrane-binding modes to amyloid fibril formation.
  COMMUNICATIONS BIOLOGY, 2018.
  DOI: 10.1038/s42003-018-0049-z

• TO Mason, TCT Michaels, A Levin, CM Dobson, E Gazit, TPJ Knowles, AK Buell.
  Thermodynamics of Polypeptide Supramolecular Assembly in the Short-Chain Limit.
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2017.
  DOI: 10.1021/jacs.7b00229
• MM Wordehoff, H Shaykhalishahi, L Gross, L Gremer, M Stoldt, AK Buell, D Willbold, W Hoyer.
  Opposed Effects of Dityrosine Formation in Soluble and Aggregated alpha-Synuclein on Fibril Growth.
  JOURNAL OF MOLECULAR BIOLOGY, 2017.
  DOI: 10.1016/j.jmb.2017.09.005
• G Meisl, L Rajah, SAI Cohen, M Pfammatter, A Saric, E Hellstrand, AK Buell, A Aguzzi, S Linse, M Vendruscolo, CM Dobson, TPJ Knowles.
  Scaling behaviour and rate-determining steps in filamentous self-assembly.
  CHEMICAL SCIENCE, 2017.
  DOI: 10.1039/c7sc01965c
• E Fisher, YY Zhao, R Richardson, M Janik, AK Buell, FI Aigbirhio, G Toth.
  Detection and Characterization of Small Molecule Interactions with Fibrillar Protein Aggregates Using Microscale Thermophoresis.
  ACS CHEMICAL NEUROSCIENCE, 2017.
  DOI: 10.1021/acschemneuro.7b00228
• M Iljina, L Hong, MH Horrocks, MH Ludtmann, ML Choi, CD Hughes, FS Ruggeri, T Guilliams, AK Buell, JE Lee, S Gandhi, SF Lee, CE Bryant, M Vendruscolo, TPJ Knowles, CM Dobson, E DeGenst, D Klenerman.
  Nanobodies raised against monomeric alpha-synuclein inhibit fibril formation and destabilize toxic oligomeric species.
  BMC BIOLOGY, 2017.
  DOI: 10.1186/s12915-017-0390-6
• C Dammers, M Schwarten, AK Buell, D Willbold.
  Pyroglutamate-modified A beta(3-42) affects aggregation kinetics of A beta(1-42) by accelerating primary and secondary pathways.
  CHEMICAL SCIENCE, 2017.
  DOI: 10.1039/c6sc04797a
• R Gaspar, G Meisl, AK Buell, L Young, CF Kaminski, TPJ Knowles, E Sparr, S Linse.
  Secondary nucleation of monomers on fibril surface dominates alpha-synuclein aggregation and provides autocatalytic amyloid amplification.
  QUARTERLY REVIEWS OF BIOPHYSICS, 2017.
  DOI: 10.1017/S0033583516000172
• R Gaspar, G Meisl, AK Buell, L Young, CF Kaminski, TPJ Knowles, E Sparr, S Linse.
  Acceleration of alpha-synuclein aggregation.
  AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS, 2017.
  DOI: 10.1080/13506129.2017.1292904
• AK Buell.
  The Nucleation of Protein Aggregates – From Crystals to Amyloid Fibrils.
  EARLY STAGE PROTEIN MISFOLDING AND AMYLOID AGGREGATION, 2017.
  DOI: 10.1016/bs.ircmb.2016.08.014

• JWP Brown, AK Buell, TCT Michaels, G Meisl, J Carozza, P Flagmeier, M Vendruscolo, TPJ Knowles, CM Dobson, C Galvagnion.
  beta-Synuclein suppresses both the initiation and amplification steps of alpha-synuclein aggregation via competitive binding to surfaces.
  SCIENTIFIC REPORTS, 2016.
  DOI: 10.1038/srep36010
• Y Zhang, AK Buell, T Muller, E DeGenst, J Benesch, CM Dobson, TPJ Knowles.
  Protein Aggregate-Ligand Binding Assays Based on Microfluidic Diffusional Separation.
  CHEMBIOCHEM, 2016.
  DOI: 10.1002/cbic.201600384
• G Costantini, Z Budrikis, A Taloni, AK Buell, S Zapperi, CAM LaPorta.
  Fluctuations in Protein Aggregation: Design of Preclinical Screening for Early Diagnosis of Neurodegenerative Disease.
  PHYSICAL REVIEW APPLIED, 2016.
  DOI: 10.1103/PhysRevApplied.6.034012
• P Flagmeier, G Meisl, M Vendruscolo, TPJ Knowles, CM Dobson, AK Buell, C Galvagnion.
  Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of alpha-synuclein aggregation.
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016.
  DOI: 10.1073/pnas.1604645113
• A Saric, AK Buell, G Meisl, TCT Michaels, CM Dobson, S Linse, TPJ Knowles, D Frenkel.
  Physical determinants of the self-replication of protein fibrils.
  NATURE PHYSICS, 2016.
  DOI: 10.1038/NPHYS3828
• TO Mason, TCT Michaels, A Levin, E Gazit, CM Dobson, AK Buell, TPJ Knowles.
  Synthesis of Nonequilibrium Supramolecular Peptide Polymers on a Microfluidic Platform.
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016.
  DOI: 10.1021/jacs.6b04136
• C Galvagnion, JWP Brown, MM Ouberai, P Flagmeier, M Vendruscolo, AK Buell, E Sparr, CM Dobson.
  Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of alpha-synuclein.
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016.
  DOI: 10.1073/pnas.1601899113
• D Pinotsi, CH Michel, AK Buell, RF Laine, P Mahou, CM Dobson, CF Kaminski, GSK Schierle.
  Nanoscopic insights into seeding mechanisms and toxicity of alpha-synuclein species in neurons.
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016.
  DOI: 10.1073/pnas.1516546113
• M Wolff, JJ Mittag, TW Herling, E DeGenst, CM Dobson, TPJ Knowles, D Braun, AK Buell.
  Quantitative thermophoretic study of disease-related protein aggregates.
  SCIENTIFIC REPORTS, 2016.
  DOI: 10.1038/srep22829

• TCT Michaels, P Yde, JCW Willis, MH Jensen, D Otzen, CM Dobson, AK Buell, TPJ Knowles.
  The length distribution of frangible biofilaments.
  JOURNAL OF CHEMICAL PHYSICS, 2015.
  DOI: 10.1063/1.4933230
• AK Buell, C Galvagnion, CM Dobson, TPJ Knowles.
  New insights into the mechanism of amyloid formation by alpha-synuclein.
  EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2015.
• IM vanderWateren, AK Buell, C Galvagnion, EV Yates, CM Dobson.
  Thioflavin-T: application for alpha-synuclein aggregation kinetics.
  EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2015.
• C Galvagnion, AK Buell.
  Fundamental mechanisms of amyloid fibers by the formation of a-synuclein protein in Parkinson’s disease quantitative Modeling.
  M S-MEDECINE SCIENCES, 2015.
  DOI: 10.1051/medsci/20153106008
• C Huynen, N Willet, AK Buell, AS Duwez, C Jerome, M Dumoulin.
  Influence of the protein context on the polyglutamine length-dependent elongation of amyloid fibrils.
  BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2015.
  DOI: 10.1016/j.bbapap.2014.12.002
• C Galvagnion, AK Buell, G Meisl, TCT Michaels, M Vendruscolo, TPJ Knowles, CM Dobson.
  Lipid vesicles trigger alpha-synuclein aggregation by stimulating primary nucleation.
  NATURE CHEMICAL BIOLOGY, 2015.
  DOI: 10.1038/NCHEMBIO.1750
• U Shimanovich, I Efimov, TO Mason, P Flagmeier, AK Buell, A Gedanken, S Linse, KS Akerfeldt, CM Dobson, DA Weitz, TPJ Knowles.
  Protein Microgels from Amyloid Fibril Networks.
  ACS NANO, 2015.
  DOI: 10.1021/nn504869d

• A Levin, TO Mason, L Adler-Abramovich, AK Buell, G Meisl, C Galvagnion, Y Bram, SA Stratford, CM Dobson, TPJ Knowles, E Gazit.
  Ostwald’s rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers.
  NATURE COMMUNICATIONS, 2014.
  DOI: 10.1038/ncomms6219
• AK Buell, C Galvagnion, R Gaspar, E Sparr, M Vendruscolo, TPJ Knowles, S Linse, CM Dobson.
  Solution conditions determine the relative importance of nucleation and growth processes in alpha-synuclein aggregation.
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014.
  DOI: 10.1073/pnas.1315346111
• N Lorenzen, SB Nielsen, AK Buell, JD Kaspersen, P Arosio, BS Vad, W Paslawski, G Christiansen, Z Valnickova-Hansen, M Andreasen, JJ Enghild, JS Pedersen, CM Dobson, TPJ Knowles, DE Otzen.
  The Role of Stable alpha-Synuclein Oligomers in the Molecular Events Underlying Amyloid Formation.
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014.
  DOI: 10.1021/ja411577t
• SIA Cohen, L Rajah, CH Yoon, AK Buell, DA White, RA Sperling, M Vendruscolo, EM Terentjev, CM Dobson, DA Weitz, TPJ Knowles.
  Spatial Propagation of Protein Polymerization.
  PHYSICAL REVIEW LETTERS, 2014.
  DOI: 10.1103/PhysRevLett.112.098101
• TCT Michaels, AK Buell, EM Terentjev, TPJ Knowles.
  Quantitative Analysis of Diffusive Reactions at the Solid-Liquid Interface in Finite Systems.
  JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 2014.
  DOI: 10.1021/jz4024833
• G Toth, SJ Gardai, W Zago, CW Bertoncini, N Cremades, SL Roy, MA Tambe, JC Rochet, C Galvagnion, G Skibinski, S Finkbeiner, M Bova, K Regnstrom, SS Chiou, J Johnston, K Callaway, JP Anderson, MF Jobling, AK Buell, TA Yednock, TPJ Knowles, M Vendruscolo, J Christodoulou, CM Dobson, D Schenk, L McConlogue.
  Targeting the Intrinsically Disordered Structural Ensemble of alpha-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease.
  PLOS ONE, 2014.
  DOI: 10.1371/journal.pone.0087133
• TO Mason, DY Chirgadze, A Levin, L Adler-Abramovich, E Gazit, TPJ Knowles, AK Buell.
  Expanding the Solvent Chemical Space for Self-Assembly of Dipeptide Nanostructures.
  ACS NANO, 2014.
  DOI: 10.1021/nn404237f
• FA Aprile, G Meisl, AK Buell, P Flagmeier, CM Dobson, M Vendruscolo, TPJ Knowles.
  Determination of Primary Nucleation Mechanisms of alpha-Synuclein Amyloid Aggregation.
  BIOPHYSICAL JOURNAL, 2014.
• AK Buell, CM Dobson, TPJ Knowles.
  The physical chemistry of the amyloid phenomenon: thermodynamics and kinetics of filamentous protein aggregation.
  AMYLOIDS IN HEALTH AND DISEASE, 2014.
  DOI: 10.1042/BSE0560011
• D Pinotsi, AK Buell, C Galvagnion, CM Dobson, GSK Schierle, CF Kaminski.
  Direct Observation of Heterogeneous Amyloid Fibril Growth Kinetics via Two-Color Super-Resolution Microscopy.
  NANO LETTERS, 2014.
  DOI: 10.1021/nl4041093

• A Pica, A Merlino, AK Buell, TPJ Knowles, E Pizzo, G D’Alessio, F Sica, L Mazzarella.
  Three-dimensional domain swapping and supramolecular protein assembly: insights from the X-ray structure of a dimeric swapped variant of human pancreatic RNase.
  ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2013.
  DOI: 10.1107/S0907444913020507
• T Guilliams, F El-Turk, AK Buell, EM O’Day, FA Aprile, EK Esbjorner, M Vendruscolo, N Cremades, E Pardon, L Wyns, ME Welland, J Steyaert, J Christodoulou, CM Dobson, E DeGenst.
  Nanobodies Raised against Monomeric alpha-Synuclein Distinguish between Fibrils at Different Maturation Stages.
  JOURNAL OF MOLECULAR BIOLOGY, 2013.
  DOI: 10.1016/j.jmb.2013.01.040
• D Pinotsi, AK Buell, CM Dobson, GSK Schierle, CF Kaminski.
  A Label-Free, Quantitative Assay of Amyloid Fibril Growth Based on Intrinsic Fluorescence.
  CHEMBIOCHEM, 2013.
  DOI: 10.1002/cbic.201300103
• LQ Xu, S Wu, AK Buell, SIA Cohen, LJ Chen, WH Hu, SA Cusack, LS Itzhaki, H Zhang, TPJ Knowles, CM Dobson, ME Welland, GW Jones, S Perrett.
  Influence of specific HSP70 domains on fibril formation of the yeast prion protein Ure2.
  PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2013.
  DOI: 10.1098/rstb.2011.0410
• AK Buell, P Hung, X Salvatella, ME Welland, CM Dobson, TPJ Knowles.
  Electrostatic Effects in Filamentous Protein Aggregation.
  BIOPHYSICAL JOURNAL, 2013.
  DOI: 10.1016/j.bpj.2013.01.031

• C Roodveldt, A Andersson, EJ DeGenst, A Labrador-Garrido, AK Buell, CM Dobson, GG Tartaglia, M Vendruscolo.
  A Rationally Designed Six-Residue Swap Generates Comparability in the Aggregation Behavior of alpha-Synuclein and beta-Synuclein.
  BIOCHEMISTRY, 2012.
  DOI: 10.1021/bi300558q
• AK Buell, CM Dobson, ME Welland.
  Measuring the Kinetics of Amyloid Fibril Elongation Using Quartz Crystal Microbalances.
  AMYLOID PROTEINS: METHODS AND PROTOCOLS, SECOND EDITION, 2012.
  DOI: 10.1007/978-1-61779-551-0_8
• AK Buell, A Dhulesia, DA White, TPJ Knowles, CM Dobson, ME Welland.
  Detailed Analysis of the Energy Barriers for Amyloid Fibril Growth.
  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012.
  DOI: 10.1002/anie.201108040

• SL Shammas, CA Waudby, SY Wang, AK Buell, TPJ Knowles, H Ecroyd, ME Welland, JA Carver, CM Dobson, S Meehan.
  Binding of the Molecular Chaperone alpha B-Crystallin to A beta Amyloid Fibrils Inhibits Fibril Elongation.
  BIOPHYSICAL JOURNAL, 2011.
  DOI: 10.1016/j.bpj.2011.07.056
• AK Buell, A Dhulesia, MF Mossuto, N Cremades, JR Kumita, M Dumoulin, ME Welland, TPJ Knowles, X Salvatella, CM Dobson.
  Population of Nonnative States of Lysozyme Variants Drives Amyloid Fibril Formation.
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011.
  DOI: 10.1021/ja109620d
• YQ Wang, AK Buell, XY Wang, ME Welland, CM Dobson, TPJ Knowles, S Perrett.
  Relationship between Prion Propensity and the Rates of Individual Molecular Steps of Fibril Assembly.
  JOURNAL OF BIOLOGICAL CHEMISTRY, 2011.
  DOI: 10.1074/jbc.M110.208934
• AK Buell, EK Esbjorner, PJ Riss, DA White, FI Aigbirhio, G Toth, ME Welland, CM Dobson, TPJ Knowles.
  Probing small molecule binding to amyloid fibrils.
  PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2011.
  DOI: 10.1039/c1cp22283j

• AK Buell, CM Dobson, TPJ Knowles, ME Welland.
  Interactions between Amyloidophilic Dyes and Their Relevance to Studies of Amyloid Inhibitors.
  BIOPHYSICAL JOURNAL, 2010.
  DOI: 10.1016/j.bpj.2010.08.074
• AK Buell, DA White, C Meier, ME Welland, TPJ Knowles, CM Dobson.
  Surface Attachment of Protein Fibrils via Covalent Modification Strategies.
  JOURNAL OF PHYSICAL CHEMISTRY B, 2010.
  DOI: 10.1021/jp101579n
• AK Buell, JR Blundell, CM Dobson, ME Welland, EM Terentjev, TPJ Knowles.
  Frequency Factors in a Landscape Model of Filamentous Protein Aggregation.
  PHYSICAL REVIEW LETTERS, 2010.
  DOI: 10.1103/PhysRevLett.104.228101
• DA White, AK Buell, TPJ Knowles, ME Welland, CM Dobson.
  Protein Aggregation in Crowded Environments.
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010.
  DOI: 10.1021/ja909997e
• TPJ Knowles, TW Oppenheim, AK Buell, DY Chirgadze, ME Welland.
  Nanostructured films from hierarchical self-assembly of amyloidogenic proteins.
  NATURE NANOTECHNOLOGY, 2010.
  DOI: 10.1038/NNANO.2010.26

• DA White, AK Buell, CM Dobson, ME Welland, TPJ Knowles.
  Biosensor-based label-free assays of amyloid growth.
  FEBS LETTERS, 2009.
  DOI: 10.1016/j.febslet.2009.06.008
• AK Buell, GG Tartaglia, NR Birkett, CA Waudby, M Vendruscolo, X Salvatella, ME Welland, CM Dobson, TPJ Knowles.
  Position-Dependent Electrostatic Protection against Protein Aggregation.
  CHEMBIOCHEM, 2009.
  DOI: 10.1002/cbic.200900144

• WS Hopkins, HP Loock, B Cronin, MGD Nix, AL Devine, RN Dixon, MNR Ashfold, HM Yin, SJ Rowling, A Bull, SH Kable.
  Quantitative (v, N, K(a)) product state distributions near the triplet threshold for the reaction H(2)CO -> H+HCO measured by Rydberg tagging and laser-induced fluorescence.
  JOURNAL OF PHYSICAL CHEMISTRY A, 2008.
  DOI: 10.1021/jp8021826

• HM Yin, SJ Rowling, A Bull, SH Kable.
  Photodissociation dynamics of the reaction H(2)CO -> H+HCO via the singlet (S(0)) and triplet (T(1)) surfaces.
  JOURNAL OF CHEMICAL PHYSICS, 2007.
  DOI: 10.1063/1.2752161